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A comparison between the two arms was made.

3 Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

The groups were homogenous regarding demographic and disease characteristics.

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1 Division of Oncology, Rambam Health Care Campus, Haifa, Israel.

Keywords: Cancer; Cannabis; Immunotherapy; Nivolumab; Response rate.

Implications for practice: Although the data are retrospective and a relation to cannabis composition was not detected, this information can be critical for cannabis users and indicates that caution is required when starting immunotherapy.

Included were 140 patients 89 nivolumab alone, 51 nivolumab plus cannabis with advanced melanoma, non-small cell lung cancer, and renal clear cell carcinoma.

Results: In a multivariate model, cannabis was the only significant factor that reduced RR to immunotherapy 37.

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